As you are aware, Rosetta@Home requires a ARM 64 bit image which basically limits involvement to Raspberry 4s (and a few work units for Raspberry 3s). Given this limitations, have you considered adding support for World Community Grid’s OpenPandemics (on BOINC)? It has ARM (32 bit) support and has much lower RAM requirements. This would allow many more Pi devices to lend their support
It would be fun to support multiple research programs, since they all are on the BOINC platform!